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    ZHANG Meimei,XIE Yinghua,LIU Zhaoxia,ZHANG Dongmei.Research progress on synthesis and application of caffeic acid phenethyl ester in propolis[J].Journal of Hebei University of Science and Technology,2020,41(6):528-536
    蜂膠中咖啡酸苯乙酯的合成及應用研究進展
    Research progress on synthesis and application of caffeic acid phenethyl ester in propolis
    Received:July 18, 2020  Revised:October 10, 2020
    DOI:10.7535/hbkd.2020yx06007
    中文關鍵詞:  藥物化學  蜂膠  咖啡酸苯乙酯  合成方法  藥理活性
    英文關鍵詞:medicinal chemistry  propolis  caffeic acid phenethyl ester  synthetic methods  pharmacological activity
    基金項目:國家自然科學基金(81872770,51205204); 河北省高等學?茖W技術研究重點項目(ZD2017032); 河北省大學生創新創業訓練計劃項目(201810082027)
    Author NameAffiliationE-mail
    ZHANG Meimei School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang  
    XIE Yinghua School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang xieyinghua@163.com 
    LIU Zhaoxia School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang  
    ZHANG Dongmei School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang  
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    中文摘要:
          蜂膠具有豐富而突出的生物活性,目前多被應用于食品和保健品中預防疾病?Х人岜揭阴ナ欠淠z中主要的有效成分,因其具有抗氧化、抗炎、抗腫瘤、抗菌、免疫調節等多種藥理作用而備受關注?Х人岜揭阴ピ谧匀唤绾科,傳統提取方法費時費力、成本高,高效、大量制備咖啡酸苯乙酯成為研究熱點。超聲提取技術可得到純度較高的咖啡酸苯乙酯;Knoevenagel縮合法適用于其工業化生產,收率較高。通過對咖啡酸苯乙酯的提取分離、合成方法以及藥理活性等方面的最新研究進展進行分析,綜述了咖啡酸苯乙酯的研究現狀,并對咖啡酸苯乙酯的技術發展前景和研究動向進行了展望,提出今后應尋求實用性和通用性高、操作相對簡便的制備方法并對其作用機制進行更加深入細致的探究。
    英文摘要:
          Propolis has been widely used in foods and health care products to prevent diseases due to its various and prominent biological activities. Caffeic acid phenethyl ester(CAPE) is the main active component of propolis, which has been widely studied for its various pharmacological effects such as antioxidation, anti-inflammation, antitumor, antibacterial activities, immunovegularion, and so on. The content of CAPE is very low in nature, and the traditional extraction method of CAPE is time-consuming and costly, so efficient and mass preparation for CAPE has become a research hotspot. The CAPE with high purity can be obtained by ultrasonic extraction. Knoevenagel condensation reaction can be applied to its industrial production with high yield. Based on the analysis of the latest progress in extraction and separation, synthetic methods, pharmacological activity, and other aspects of CAPE, the research status of CAPE was reviewed, and the development prospect and the research trend of CAPE were provided, which are to explore the preparation method with high practicability and generality and relatively simple operation, and to conduct in-depth and detailed research on the mechanism of CAPE.
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